Facing cinacalcet-induced hypocalcemia: sit back and relax? | Zendy

Pieter Evenepoel | Zendy; Rukshana Shroff | Zendy

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Facing cinacalcet-induced hypocalcemia: sit back and relax?

Author(s) -

Pieter Evenepoel,

Rukshana Shroff

Publication year - 2018

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1016/j.kint.2018.01.038

Subject(s) - cinacalcet , medicine , asymptomatic , post hoc analysis , warrant , calcium , parathyroid hormone , secondary hyperparathyroidism , financial economics , economics

A post hoc analysis of data from the EVOLVE study demonstrates that cinacalcet-induced hypocalcemia is common, mostly asymptomatic, and resolves spontaneously. These findings are reassuring and may warrant therapeutic inertia. However, previous studies in parathyroidectomized patients suggest that calcium repletion may be beneficial and safe from bone and cardiovascular perspectives, respectively, and as such call into question the appropriateness of a "sit back and relax" attitude toward cinacalcet-induced hypocalcemia.

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