Toward individual glomerular phenotyping: advent of precision medicine in kidney biopsies | Zendy

Kumar Sharma | Zendy; Ljiljana PašaTolić | Zendy

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Toward individual glomerular phenotyping: advent of precision medicine in kidney biopsies

Author(s) -

Kumar Sharma,

Ljiljana PašaTolić

Publication year - 2018

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1016/j.kint.2018.01.035

Subject(s) - nephrology , glomerulus , renal function , renal biopsy , pathology , medicine , renal pathology , glomerulosclerosis , proteinuria , kidney , kidney glomerulus , renal glomerulus , podocyte , biopsy , glomerulonephritis , biology

The road to precision medicine for nephrology is approaching quickly. In the present volume, the glomerular proteome has now been characterized at a single glomerulus level in mouse and human kidneys. Using the Single-Pot Solid-Phase-enhanced Sample Preparation (SP3) approach the authors demonstrated that LAMP1 is a key lysosomal protein that is increased in glomerular diseases and may play a pathogenic role.

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