Open AccessA novel role for renal epithelial cells and the medullary sodium gradient in the local immune response
Author(s) -
Christina Wyatt,
Steven D. Crowley
Publication year - 2017
Publication title -
kidney international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.499
H-Index - 276
eISSN - 1523-1755
pISSN - 0085-2538
DOI - 10.1016/j.kint.2017.10.005
Subject(s) - immune system , chemokine , biology , population , immunology , kidney , microbiology and biotechnology , pathology , medicine , endocrinology , environmental health
The extreme hypertonicity of the renal medulla plays a central role in regulating volume status. A recent publication in Cell has identified a novel role for the high sodium environment and the local epithelial cells in the recruitment of mononuclear phagocytes, potentially contributing to the defense against ascending urinary tract infection.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom