The function of the parathyroid oxyphil cells in uremia: still a mystery? | Zendy

Carlo Basile | Zendy; Carlo Lomonte | Zendy

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The function of the parathyroid oxyphil cells in uremia: still a mystery?

Author(s) -

Carlo Basile,

Carlo Lomonte

Publication year - 2017

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1016/j.kint.2017.06.024

Subject(s) - transdifferentiation , medicine , parathyroid chief cell , secondary hyperparathyroidism , gastric chief cell , endocrinology , cell type , cell , pathology , stem cell , parathyroid hormone , biology , microbiology and biotechnology , calcium , stomach , gastric mucosa , genetics

Parathyroid glands of young adults consist primarily of chief cells. However, with age or after excessive functional stress, another cell type increases progressively-the oxyphil cell. There is evidence for a chief-to-oxyphil cell transdifferentiation in chronic kidney disease. The latter may represent a defense mechanism, transforming the actively secreting chief cells to a less actively secreting cell type. However, even if this strategy is able to delay the development of secondary hyperparathyroidism, it cannot prevent it.

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