Going single but not solo with podocytes: potentials, limitations, and pitfalls of single-cell analysis | Zendy

Mario Schiffer | Zendy

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Going single but not solo with podocytes: potentials, limitations, and pitfalls of single-cell analysis

Author(s) -

Mario Schiffer

Publication year - 2017

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1016/j.kint.2017.05.033

Subject(s) - transcriptome , rna , computational biology , biology , cell , single cell analysis , rna seq , single cell sequencing , gene expression , gene , microbiology and biotechnology , genetics , phenotype , exome sequencing

Single-cell RNA-sequence (RNA-seq) is a widely used tool to study biological questions in single cells. The discussed study identified 92 genes being predominantly expressed in podocytes based on a 5-fold higher expression compared with endothelial and mesangial cells. In addition to technical pitfalls, the question that is discussed in this commentary is whether results of a single-cell RNAseq study are able to deliver expression data that truly characterize a podocyte.

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