Is osteocyte Klotho bad for bone health? | Zendy

Rosa Maria Affonso Moysés | Zendy; Adriana Dusso | Zendy

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Is osteocyte Klotho bad for bone health?

Author(s) -

Rosa Maria Affonso Moysés,

Adriana Dusso

Publication year - 2017

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1016/j.kint.2017.04.012

Subject(s) - klotho , osteocyte , fibroblast growth factor 23 , medicine , endocrinology , bone remodeling , sclerostin , microbiology and biotechnology , chemistry , calcium , biology , osteoblast , signal transduction , kidney , parathyroid hormone , biochemistry , in vitro , wnt signaling pathway

The recent identification of αKlotho protein (Klotho) in osteocytes led to the generation of an experimental mouse model with osteocyte-specific Klotho ablation. This enabled Komaba et al. to assess the contribution to bone structure and function of osteocyte Klotho per se as compared with that of the systemic fibroblast growth factor 23-Klotho axis. Surprisingly, unlike the osteopenia and low bone turnover of systemic Klotho deletion, osteocyte-specific Klotho ablation resulted in increased osteoblastic activity and bone formation rate.

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