Treatment tolerance and patient-reported outcomes favor online hemodiafiltration compared to high-flux hemodialysis in the elderly | Zendy

Marion Moréna | Zendy; Audrey Jaussent | Zendy; Lotfi Chalabi | Zendy; Hélène LerayMoragues | Zendy; Leïla Chénine | Zendy; A. Debure | Zendy; Damien Thibaudin | Zendy; Lynda Azzouz | Zendy; Laure Patrier | Zendy; François Maurice | Zendy; Philippe Nicoud | Zendy; C Durand | Zendy; Bruno Seigneuric | Zendy; AnneMarie Dupuy | Zendy; MarieChristine Picot | Zendy; JeanPaul Cristol | Zendy; Bernard Canaud | Zendy; Aïda Afiani | Zendy; Didier Aguiléra | Zendy; Yamina Azymah | Zendy; F. Babinet | Zendy; C. Belloc | Zendy; Jean- Christophe Bendini | Zendy; Christian Broyet | Zendy; Philippe Brunet | Zendy; Marie-Hélêne Chabannier | Zendy; S. Chiron | Zendy; Jean-Philippe Coindre | Zendy; Angélique Colin | Zendy; François Combarnous | Zendy; Stéphanie Coupel | Zendy; A. Crémault | Zendy; Irima Dancea | Zendy; Catherine Delcroix | Zendy; Pascale Depraêtre | Zendy; Assia Djema | Zendy; Françis Ducret | Zendy; Ibrahim O. Farah | Zendy; D. Fleury | Zendy; Abdallah Guerraoui | Zendy; Marie-Paule Guillodo | Zendy; Atman Haddj-Elmrabet | Zendy; Maxime Hoffmann | Zendy; Richard Ibos | Zendy; Mohamed Shariful Islam | Zendy; D Jaubert | Zendy; J. W. Joule | Zendy; V. Joyeux | Zendy; Kristian Kunz | Zendy; Mélodie Lagarrigue | Zendy; A. Laradi | Zendy; Frédéric Lavainne | Zendy; Dominique Le Grignou | Zendy; Gaétan Lebrun | Zendy; Anne Lefebvre | Zendy; Jean-Jacques Lefevre | Zendy; Gaëlle Lefrançois | Zendy; Vincent Lemaître | Zendy; Mehadji Maaz | Zendy; Éric Magnant | Zendy; Hesham Mohey | Zendy; Michel Normand | Zendy; Hilaire Nzeyimana | Zendy; Messaoud Ouziala | Zendy; Sophie Parahy | Zendy; Franck Perrin | Zendy; P Pointet | Zendy; J. Potier | Zendy; Olivier Puyoo | Zendy; Isabelle Rey | Zendy; Jean-Pierre Rivory | Zendy; Fabienne Rouleau | Zendy; Marie-Odile Serveaux | Zendy; Danlèle Simonin | Zendy; Angelo Testa | Zendy; C. Turc-Baron | Zendy; Carlos Vela | Zendy; Sandor Vido | Zendy; Laurence Vrigneaud | Zendy

Open Access

Treatment tolerance and patient-reported outcomes favor online hemodiafiltration compared to high-flux hemodialysis in the elderly

Author(s) -

Marion Moréna,

Audrey Jaussent,

Lotfi Chalabi,

Hélène LerayMoragues,

Leïla Chénine,

A. Debure,

Damien Thibaudin,

Lynda Azzouz,

Laure Patrier,

François Maurice,

Philippe Nicoud,

C Durand,

Bruno Seigneuric,

AnneMarie Dupuy,

MarieChristine Picot,

JeanPaul Cristol,

Bernard Canaud,

Aïda Afiani,

Didier Aguiléra,

Yamina Azymah,

F. Babinet,

C. Belloc,

Jean- Christophe Bendini,

Christian Broyet,

Philippe Brunet,

Marie-Hélêne Chabannier,

S. Chiron,

Jean-Philippe Coindre,

Angélique Colin,

François Combarnous,

Stéphanie Coupel,

A. Crémault,

Irima Dancea,

Catherine Delcroix,

Pascale Depraêtre,

Assia Djema,

Françis Ducret,

Ibrahim O. Farah,

D. Fleury,

Abdallah Guerraoui,

Marie-Paule Guillodo,

Atman Haddj-Elmrabet,

Maxime Hoffmann,

Richard Ibos,

Mohamed Shariful Islam,

D Jaubert,

J. W. Joule,

V. Joyeux,

Kristian Kunz,

Mélodie Lagarrigue,

A. Laradi,

Frédéric Lavainne,

Dominique Le Grignou,

Gaétan Lebrun,

Anne Lefebvre,

Jean-Jacques Lefevre,

Gaëlle Lefrançois,

Vincent Lemaître,

Mehadji Maaz,

Éric Magnant,

Hesham Mohey,

Michel Normand,

Hilaire Nzeyimana,

Messaoud Ouziala,

Sophie Parahy,

Franck Perrin,

P Pointet,

J. Potier,

Olivier Puyoo,

Isabelle Rey,

Jean-Pierre Rivory,

Fabienne Rouleau,

Marie-Odile Serveaux,

Danlèle Simonin,

Angelo Testa,

C. Turc-Baron,

Carlos Vela,

Sandor Vido,

Laurence Vrigneaud

Publication year - 2017

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1016/j.kint.2017.01.013

Subject(s) - hemodialysis , medicine , intensive care medicine , flux (metallurgy) , materials science , metallurgy

Large cohort studies suggest that high convective volumes associated with online hemodiafiltration may reduce the risk of mortality/morbidity compared to optimal high-flux hemodialysis. By contrast, intradialytic tolerance is not well studied. The aim of the FRENCHIE (French Convective versus Hemodialysis in Elderly) study was to compare high-flux hemodialysis and online hemodiafiltration in terms of intradialytic tolerance. In this prospective, open-label randomized controlled trial, 381 elderly chronic hemodialysis patients (over age 65) were randomly assigned in a one-to-one ratio to either high-flux hemodialysis or online hemodiafiltration. The primary outcome was intradialytic tolerance (day 30-day 120). Secondary outcomes included health-related quality of life, cardiovascular risk biomarkers, morbidity, and mortality. During the observational period for intradialytic tolerance, 85% and 84% of patients in high-flux hemodialysis and online hemodiafiltration arms, respectively, experienced at least one adverse event without significant difference between groups. As exploratory analysis, intradialytic tolerance was also studied, considering the sessions as a statistical unit according to treatment actually received. Over a total of 11,981 sessions, 2,935 were complicated by the occurrence of at least one adverse event, with a significantly lower occurrence in online hemodiafiltration with fewer episodes of intradialytic symptomatic hypotension and muscle cramps. By contrast, health-related quality of life, morbidity, and mortality were not different in both groups. An improvement in the control of metabolic bone disease biomarkers and β2-microglobulin level without change in serum albumin concentration was observed with online hemodiafiltration. Thus, overall outcomes favor online hemodiafiltration over high-flux hemodialysis in the elderly.

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