Mitochondrial dysfunction in obesity-related kidney disease: a novel therapeutic target | Zendy

Chengyuan Tang | Zendy; Juan Cai | Zendy; Zheng Dong | Zendy

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Mitochondrial dysfunction in obesity-related kidney disease: a novel therapeutic target

Author(s) -

Chengyuan Tang,

Juan Cai,

Zheng Dong

Publication year - 2016

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1016/j.kint.2016.07.045

Subject(s) - glomerulopathy , pathogenesis , mitochondrion , kidney , disease , medicine , kidney disease , obesity , mechanism (biology) , bioinformatics , endocrinology , biology , glomerulonephritis , microbiology and biotechnology , philosophy , epistemology

Lipid accumulation in renal cells has been implicated in the pathogenesis of obesity-related kidney disease, but the underlying mechanism is poorly understood. Szeto et al. now unravel a central role of mitochondrial dysfunction in a high fat diet-induced glomerulopathy and proximal tubular injury. Moreover, they demonstrate the renoprotective effect of SS31, a mitochondria-targeted antioxidant, in related models. Targeting mitochondria may offer a novel strategy for the therapy of obesity-related kidney disease.

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