Timing is everything? Reconciling the results of recent trials in acute kidney injury | Zendy

Christina Wyatt | Zendy; Steven G. Coca | Zendy

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Timing is everything? Reconciling the results of recent trials in acute kidney injury

Author(s) -

Christina Wyatt,

Steven G. Coca

Publication year - 2016

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1016/j.kint.2016.07.006

Subject(s) - observational study , medicine , intensive care medicine , acute kidney injury , renal replacement therapy , harm , randomized controlled trial , intensive care unit , clinical trial , critically ill , psychology , social psychology

Observational studies have failed to establish the optimal timing of renal replacement therapy in critically ill adults with acute kidney injury, with some studies suggesting benefit and others suggesting the potential for harm with earlier initiation. Two recent randomized trials have addressed this controversy, also with conflicting results. Careful consideration of differences between the 2 studies is essential when applying the results to clinical practice in the intensive care unit.

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