APOL1 risk variants and death among African American hemodialysis patients: survival of the fittest? | Zendy

Teresa K. Chen | Zendy; Michelle M. Estrella | Zendy

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APOL1 risk variants and death among African American hemodialysis patients: survival of the fittest?

Author(s) -

Teresa K. Chen,

Michelle M. Estrella

Publication year - 2016

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1016/j.kint.2016.03.024

Subject(s) - medicine , hemodialysis , cohort , disease , epidemiology , population , kidney disease , cohort study , end stage renal disease , mortality rate , intensive care medicine , environmental health

Recent studies have focused on associations of the APOL1 risk variants with outcomes beyond kidney disease, including cardiovascular disease and mortality. Ma and colleagues now expand on this growing but contradicting body of work. Their analysis of a prevalent cohort of African American hemodialysis patients shows that the risk variants are associated with a survival benefit among nondiabetics. Whether this simply reflects a healthier status at hemodialysis initiation among those carrying 2 risk variants or whether these variants truly confer a survival advantage is unclear.

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