Epithelial-to-mesenchymal transition of tubular epithelial cells in renal fibrosis: a new twist on an old tale | Zendy

Madhav C. Me | Zendy; Michael J. Ross | Zendy

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Epithelial-to-mesenchymal transition of tubular epithelial cells in renal fibrosis: a new twist on an old tale

Author(s) -

Madhav C. Me,

Michael J. Ross

Publication year - 2016

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1016/j.kint.2015.12.025

Subject(s) - epithelial–mesenchymal transition , myofibroblast , mesenchymal stem cell , fibrosis , pathology , epithelium , kidney , twist , microbiology and biotechnology , transition (genetics) , biology , medicine , chemistry , cancer research , endocrinology , biochemistry , gene , geometry , mathematics

Recent publications have questioned whether epithelial-to-mesenchymal transition of tubular epithelial cells is an important contributor to renal fibrosis. Two recent publications describe an intratubular epithelial-to-mesenchymal transition-like program of epithelial cell dedifferentiation that may contribute to the recruitment or proliferation of interstitial myofibroblasts after kidney injury.

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