Open AccessProtamine Sulfate Induced Bladder Injury Protects from Distention Induced Bladder Pain
Author(s) -
Kristina M. Stemler,
Lara W. Crock,
H. Henry Lai,
Jason C. Mills,
Robert W. Gereau,
Indira U. Mysorekar
Publication year - 2013
Publication title -
the journal of urology/the journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.402
H-Index - 256
eISSN - 1527-3792
pISSN - 0022-5347
DOI - 10.1016/j.juro.2012.08.189
Subject(s) - medicine , st louis , anesthesiology , pain medicine , obstetrics and gynaecology , general surgery , family medicine , history , pathology , art history , pregnancy , genetics , biology
Bladder pain is a debilitating symptom of many urological conditions. There is no generally effective treatment. Abnormal urothelial turnover is common to multiple disease states but the specific components of urothelial injury and the resulting molecular signals that lead to bladder pain are unknown. We examined mouse models of bladder injury induced by uropathogenic Escherichia coli, protamine sulfate (Sigma®) and bacterial lipopolysaccharide to identify cellular and molecular correlates underlying pain sensitization in response to the stimuli.