Hemodynamic and transcriptomic studies suggest early left ventricular dysfunction in a preclinical model of severe mitral regurgitation | Zendy

Daniella Corporan | Zendy; Daisuke Onohara | Zendy; Alan Amedi | Zendy; Maher Saadeh | Zendy; Robert A. Guyton | Zendy; Sandeep Kumar | Zendy; Muralidhar Padala | Zendy

Open Access

Hemodynamic and transcriptomic studies suggest early left ventricular dysfunction in a preclinical model of severe mitral regurgitation

Author(s) -

Daniella Corporan,

Daisuke Onohara,

Alan Amedi,

Maher Saadeh,

Robert A. Guyton,

Sandeep Kumar,

Muralidhar Padala

Publication year - 2020

Publication title -

journal of thoracic and cardiovascular surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.458

H-Index - 192

eISSN - 1085-8687

pISSN - 0022-5223

DOI - 10.1016/j.jtcvs.2020.08.119

Subject(s) - ejection fraction , cardiology , medicine , mitral regurgitation , ventricular remodeling , regurgitant fraction , mitral valve , stroke volume , hemodynamics , heart failure

Primary mitral regurgitation is a valvular lesion in which the left ventricular ejection fraction remains preserved for long periods, delaying a clinical trigger for mitral valve intervention. In this study, we sought to investigate whether adverse left ventricular remodeling occurs before a significant fall in ejection fraction and characterize these changes.

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