Open AccessHemodynamic and transcriptomic studies suggest early left ventricular dysfunction in a preclinical model of severe mitral regurgitation
Author(s) -
Daniella Corporan,
Daisuke Onohara,
Alan Amedi,
Maher Saadeh,
Robert A. Guyton,
Sandeep Kumar,
Muralidhar Padala
Publication year - 2020
Publication title -
journal of thoracic and cardiovascular surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.458
H-Index - 192
eISSN - 1085-8687
pISSN - 0022-5223
DOI - 10.1016/j.jtcvs.2020.08.119
Subject(s) - ejection fraction , cardiology , medicine , mitral regurgitation , ventricular remodeling , regurgitant fraction , mitral valve , stroke volume , hemodynamics , heart failure
Primary mitral regurgitation is a valvular lesion in which the left ventricular ejection fraction remains preserved for long periods, delaying a clinical trigger for mitral valve intervention. In this study, we sought to investigate whether adverse left ventricular remodeling occurs before a significant fall in ejection fraction and characterize these changes.