Pulsed ultrasound attenuates the hyperglycemic exacerbation of myocardial ischemia–reperfusion injury | Zendy

Eric J. Charles | Zendy; Yikui Tian | Zendy; Aimee Zhang | Zendy; Di Wu | Zendy; J. Hunter Mehaffey | Zendy; Joseph C. Gigliotti | Zendy; Alexander L. Klibanov | Zendy; Irving L. Kron | Zendy; Zequan Yang | Zendy

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Pulsed ultrasound attenuates the hyperglycemic exacerbation of myocardial ischemia–reperfusion injury

Author(s) -

Eric J. Charles,

Yikui Tian,

Aimee Zhang,

Di Wu,

J. Hunter Mehaffey,

Joseph C. Gigliotti,

Alexander L. Klibanov,

Irving L. Kron,

Zequan Yang

Publication year - 2019

Publication title -

journal of thoracic and cardiovascular surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.458

H-Index - 192

eISSN - 1085-8687

pISSN - 0022-5223

DOI - 10.1016/j.jtcvs.2019.10.096

Subject(s) - medicine , reperfusion injury , myocardial infarction , ultrasound , ischemia , cardiology , exacerbation , anesthesia , radiology

Acute hyperglycemia during myocardial infarction worsens outcomes in part by inflammatory mechanisms. Pulsed ultrasound has anti-inflammatory potential in bone healing and neuromodulation. We hypothesized that pulsed ultrasound would attenuate the hyperglycemic exacerbation of myocardial ischemia-reperfusion injury via the cholinergic anti-inflammatory pathway.

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