CD3+CD4–CD8– Double-negative αβ T cells attenuate lung ischemia-reperfusion injury | Zendy

Joshua Hsu | Zendy; Aravind Krishnan | Zendy; Sul A Lee | Zendy; J.M. Dodd-o | Zendy; Bo Kim | Zendy; Peter B. Illei | Zendy; Kristine Yarnoff | Zendy; Abdel A Hamad | Zendy; Hamid Rabb | Zendy; Errol L. Bush | Zendy

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CD3+CD4–CD8– Double-negative αβ T cells attenuate lung ischemia-reperfusion injury

Author(s) -

Joshua Hsu,

Aravind Krishnan,

Sul A Lee,

J.M. Dodd-o,

Bo Kim,

Peter B. Illei,

Kristine Yarnoff,

Abdel A Hamad,

Hamid Rabb,

Errol L. Bush

Publication year - 2019

Publication title -

journal of thoracic and cardiovascular surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.458

H-Index - 192

eISSN - 1085-8687

pISSN - 0022-5223

DOI - 10.1016/j.jtcvs.2019.09.188

Subject(s) - lung transplantation , cd8 , lung , reperfusion injury , ischemia , medicine , immune system , cytotoxic t cell , complication , immunology , biology , biochemistry , in vitro

Lung ischemia-reperfusion injury (IRI) is a common complication after lung transplantation, and immune cells have been implicated in modulating outcomes. We hypothesized that a newly described subset of αβ T-cell receptor positive cells; that is, CD4 - CD8 - (double negative [DN]) T cells, are found in lungs and can protect against lung IRI.

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