Pretransplant serum human chitinase-like glycoprotein YKL-40 concentrations independently predict bronchiolitis obliterans development in lung transplant recipients | Zendy

Péter Jaksch | Zendy; Shahrokh Taghavi | Zendy; Walter Klepetko | Zendy; Mohamed Salama | Zendy

Open Access

Pretransplant serum human chitinase-like glycoprotein YKL-40 concentrations independently predict bronchiolitis obliterans development in lung transplant recipients

Author(s) -

Péter Jaksch,

Shahrokh Taghavi,

Walter Klepetko,

Mohamed Salama

Publication year - 2014

Publication title -

journal of thoracic and cardiovascular surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.458

H-Index - 192

eISSN - 1085-8687

pISSN - 0022-5223

DOI - 10.1016/j.jtcvs.2014.02.059

Subject(s) - bronchiolitis obliterans , medicine , bronchoalveolar lavage , lung transplantation , odds ratio , gastroenterology , lung , biomarker , transplantation , bronchiolitis , fibrosis , pulmonary fibrosis , immunology , pathology , respiratory system , biochemistry , chemistry

Bronchiolitis obliterans syndrome (BOS) is the main long-term complication limiting survival after lung transplantation. There exists no cure for BOS and its mechanisms are not well understood. Early identification of BOS could therefore contribute to improvement of therapeutic and preventive measures. The human chitinase-like glycoprotein YKL-40 is involved in regulation of inflammatory tissue response and remodeling and is associated with pulmonary fibrosis. However, its role in BOS is unknown.

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