Open AccessDo PON1–Q192R and PON1–L55M polymorphisms modify the effects of hypoxic training on paraoxonase and arylesterase activity?
Author(s) -
Oya Yiğittürk,
Faruk Turgay,
Servet Kızıldağ,
Dua Özsoylu,
Görkem Aybars Balcı
Publication year - 2020
Publication title -
journal of sport and health science/journal of sport and health science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.386
H-Index - 36
eISSN - 2095-2546
pISSN - 2213-2961
DOI - 10.1016/j.jshs.2020.11.004
Subject(s) - pon1 , paraoxonase , arylesterase , medicine , genetics , biology , endocrinology , genotype , gene , oxidative stress
Low levels of antioxidant paraoxonase 1 (PON1) enzyme activity, PON1-Q192R polymorphism (a glutamine (Q) to arginine (R) substitution at position 192), PON1-L55M polymorphism (a leucine (L) to methionine (M) substitution at position 55), and oxidized low-density lipoprotein (oxLDL) are risk factors for coronary heart disease. Aerobic exercise improves PON1 activity, but the effects of hypoxic exercise are yet unclear. The aim of this study was to determine the effects of hypoxic underwater rugby training on PON1 activity and oxLDL levels and the role of the mentioned polymorphisms.
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