Open AccessEffect of CoO nanoparticles on the carbohydrate metabolism of the brain of mice “Mus musculus”
Author(s) -
Shamshad M. Shaikh,
Priti Desai
Publication year - 2016
Publication title -
journal of basic and applied zoology /journal of basic and applied zoology
Language(s) - English
Resource type - Journals
eISSN - 2090-9896
pISSN - 2090-990X
DOI - 10.1016/j.jobaz.2015.12.003
Subject(s) - carbohydrate metabolism , chemistry , olfactory bulb , glycogen , carbohydrate , pentose phosphate pathway , endocrinology , medicine , alkaline phosphatase , hexokinase , biochemistry , metabolism , central nervous system , biology , glycolysis , enzyme
The effect of CoO nanoparticles (NPs) on the brain of mice administered through gastrointestinal tract for a period of 30days was studied. AAS analysis revealed that NPs administered orally were retained by cerebellum, cerebral cortex, medulla oblongata and olfactory bulb. This retention of nanoparticles by the brain promoted a significant increase in glucose, pyruvate, lactate and glycogen levels along with the concomitant increase in hexokinase, glucose 6 phosphatase, and lactate dehydrogense activities. However, a decrease in glucose 6 phosphate dehydrogenase activity was observed in the brain regions indicating a deterioration of the pentose phosphate pathway. Thus, the present study suggests that the CoO NPs affect the carbohydrate metabolism of the brain