Open AccessClinical value of detection on serum monocyte chemotactant protein-1 and vascular endothelial cadherin levels in patients with acute cerebral infarction
Author(s) -
Xia Zhou,
Cheng Zhang
Publication year - 2016
Publication title -
journal of acute disease
Language(s) - English
Resource type - Journals
eISSN - 2589-5516
pISSN - 2221-6189
DOI - 10.1016/j.joad.2016.08.022
Subject(s) - medicine , mmp3 , mmp9 , mmp2 , enolase , monocyte , infarction , gastroenterology , matrix metalloproteinase , cerebral infarction , ve cadherin , myocardial infarction , cardiology , cadherin , ischemia , immunohistochemistry , downregulation and upregulation , cell , biochemistry , gene expression , chemistry , genetics , cancer , biology , gene , metastasis
ObjectiveTo study the correlation of serum monocyte chemotactant protein-1 (MCP-1) and vascular endothelia cadherin (VE-cadherin) levels in patients with acute cerebral infarction, and nerve injury molecules, interleukins and matrix metalloproteinases.MethodsA total of 86 patients with acute cerebral infarction treated in our hospital from April 2012 to October 2015 were selected as the observation group and 50 healthy subjects in the same period treated in our hospital were selected as the control group. The serums were collected and the contents of MCP-1, VE-cadherin, heart-type fatty acid binding protein (H-FABP), S100 calcium binding protein B (S100B), neuron-specific enolase (NSE), interleukin-lβ (IL-1β), IL-6, IL-17, IL-18, matrix metalloproteinase-2 (MMP2), MMP3 and MMP9 were measured.ResultsThe serum contents of MCP-1, VE-cadherin, H-FABP, S100B, NSE, IL-1β, IL-6, IL-17, IL-18, MMP2, MMP3 and MMP9 in observation group were significantly higher than those of control group. Carotid artery plaque formation and unstable plaque properties will increase the serum contents of MCP-1, VE-cadherin, H-FABP, S100B, NSE, IL-1β, IL-6, IL-17, IL-18, MMP2, MMP3 and MMP9 in patients with cerebral infarction. The serum levels of MCP-1, VE-cadherin and the contents of H-FABP, S100B, NSE, IL-1β, IL-6, IL-17, IL-18, MMP2, MMP3 and MMP9 were positively correlated.ConclusionsThe serum levels of VE-cadherin and MCP-1 were significantly increased in patients with acute cerebral infarction. MCP-1 and VE-cadherin can increase the secretion of interleukins and matrix metalloproteinases, which can result in the carotid artery plaque formation, unstable plaque properties and the injury of nerve function