Open AccessAssociation between serum soluble urokinase‐type plasminogen activator receptor and atrial fibrillation
Author(s) -
Ichihara Noboru,
Miyamura Masatoshi,
Maeda Daichi,
Fujisaka Tomohiro,
Fujita Shuichi,
Morita Hideaki,
Takeda Yoshihiro,
Ito Takahide,
Sohmiya Koichi,
Hoshiga Masaaki,
Ishizaka Nobukazu
Publication year - 2017
Publication title -
journal of arrhythmia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 21
eISSN - 1883-2148
pISSN - 1880-4276
DOI - 10.1016/j.joa.2017.05.003
Subject(s) - supar , medicine , quartile , atrial fibrillation , sinus rhythm , odds ratio , cardiology , gastroenterology , confidence interval , receiver operating characteristic , plasminogen activator , urokinase receptor
Background Circulating soluble urokinase‐type plasminogen activator receptor (suPAR), which can reflect immune activation and low‐grade inflammation, may be a novel biomarker of cardiovascular disease. Methods We investigated the potential association between suPAR and the prevalence of atrial fibrillation (AF) by analyzing patients with either sinus rhythm, paroxysmal atrial fibrillation (PAF), or non‐paroxysmal atrial fibrillation (NPAF), which indicates either permanent or persistent AF. Results Among 426 patients enrolled (mean age 71.4±9.2 years; 110 (25.8%) female), 310, 62, and 54 were diagnosed with sinus rhythm, PAF, and NPAF, respectively. NPAF was >10‐fold more prevalent in the highest suPAR quartile (>3534 pg/mL; 32 (30.2%) of 106 patients) than in the lowest suPAR quartile (<1802 pg/mL; 3 (2.8%) of 107 patients). Logistic regression analysis showed that, as compared with the lowest suPAR quartile, the highest suPAR quartile was associated with NPAF with an odds ratio of 6.48 (95% confidence interval, 1.71–24.5) after adjustment for sex, age, log(eGFR), C‐reactive protein, and systolic blood pressure. In multivariate receiver operating characteristic analysis to predict NPAF, the area under the curve (AUC) for the combination of age, sex, log(eGFR), and C‐reactive protein was 0.777 (standard error [SE], 0.036); the addition of log(suPAR) slightly improved the prediction (AUC, 0.812; SE, 0.034, P=0.084). Conclusions Serum suPAR was associated with AF, particularly NPAF, as demonstrated by multivariate logistic regression analysis. Whether suPAR promotes or maintains AF should be investigated in further studies.