English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Background  Ablation targeting complex fractionated atrial electrograms (CFAEs) or high dominant frequency (DF) sites is generally effective for persistent atrial fibrillation (AF). CFAEs and/or high DF sites may exist in low‐voltage regions, which theoretically represent abnormal substrates. However, whether CFAEs or high DF sites reflect low voltage substrates during sinus rhythm (SR) is unknown.    Methods  Sixteen patients with AF (8 with paroxysmal AF; 8, persistent AF) underwent high‐density mapping of the left atrium (LA) with a 3‐dimensional electroanatomic mapping system before ablation. The LA was divided into 7 segments and the mean bipolar voltage recorded during AF and SR, CFAEs (cycle lengths of 50–120 ms), and DF sites were assessed in each segment with either a duo‐decapolar ring catheter (n=10) or a 64‐pole basket catheter (n=6). Low‐voltage areas were defined as those of <0.5 mV during AF and <1.0 mV during SR.    Results  Regional mean voltage recorded from the basket catheter showed good correlation between AF and SR (r=0.60,  p <0.01); however, the % low‐voltage area in the LA recorded from the ring catheter showed weak correlation (r=0.34,  p =0.05). Mean voltage was lower during AF than during SR (1.0 mV [IQR, 0.5–1.4] vs. 2.6 mV [IQR, 1.8–3.6],  p <0.01). The regional and overall % low‐voltage area of the LA was greater during AF than during SR (20% vs. 11%,  p =0.05). CFAEs and high DF sites (>8 Hz) did not correlate with % low‐voltage sites during SR; however, CFAEs sites were located in high‐voltage regions during AF and high DF sites were located in low voltage regions during AF.    Conclusions  CFAEs and high DF areas during AF do not reflect damaged atrial myocardium as shown by the SR voltage. However, CFAEs and high DF sites may demonstrate different electrophysiologic properties because of different voltage amplitude during AF.

Complex fractionated atrial electrograms, high dominant frequency regions, and left atrial voltages during sinus rhythm and atrial fibrillation