Open AccessEHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: Definition, characterisation, and clinical implication
Author(s) -
Goette Andreas,
Kalman Jonathan M.,
Aguinaga Luis,
Akar Joseph,
Cabrera Jose Angel,
Chen Shih Ann,
Chugh Sumeet S.,
Corradi Domenico,
D'Avila Andre,
Dobrev Dobromir,
Fenelon Guilherme,
Gonzalez Mario,
Hatem Stephane N.,
Helm Robert,
Hindricks Gerhard,
Ho Siew Yen,
Hoit Brian,
Jalife Jose,
Kim YoungHoon,
Lip Gregory Y.H.,
Ma ChangSheng,
Marcus Gregory M.,
Murray Katherine,
Nogami Akihiko,
Sanders Prashanthan,
Uribe William,
Van Wagoner David R.,
Nattel Stanley
Publication year - 2016
Publication title -
journal of arrhythmia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 21
eISSN - 1883-2148
pISSN - 1880-4276
DOI - 10.1016/j.joa.2016.05.002
Subject(s) - medicine , cardiology , atrial fibrillation
The atria provide an important contribution to cardiac function.1,2 Besides their impact on ventricular filling, they serve as a volume reservoir, host pacemaker cells and important parts of the cardiac conduction system (e.g. sinus node, AV node), and secrete natriuretic peptides like atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) that regulate fluid homeostasis. Atrial myocardium is affected by many cardiac and non-cardiac conditions3 and is, in some respects, more sensitive than ventricular.4 The atria are activated, besides the three specialized intermodal tracts,5,6 through working cardiomyocytes, so that any architectural or structural change in the atrial myocardium may cause significant electrophysiological disturbances. In addition, atrial cells (both cardiomyocytes and non-cardiomyocyte elements like fibroblasts, endothelial cells, and neurons) react briskly and extensively to pathological stimuli3 and are susceptible to a range of genetic influences.7 Responses include atrial cardiomyocyte hypertrophy and contractile dysfunction, arrhythmogenic changes in cardiomyocyte ion-channel and transporter function, atrial fibroblast proliferation, hyperinnervation, and thrombogenic changes.2 Thus, atrial pathologies have a substantial impact on cardiac performance, arrhythmia occurrence, and stroke risk.1,8Ventricular cardiomyopathies have been well classified; however, a …