Open AccessPrevention of immediate recurrence of atrial fibrillation with low‐dose landiolol after radiofrequency catheter ablation
Author(s) -
Ishigaki Daisuke,
Arimoto Takanori,
Iwayama Tadateru,
Hashimoto Naoaki,
Kutsuzawa Daisuke,
Kumagai Yu,
Nishiyama Satoshi,
Takahashi Hiroki,
Shishido Tetsuro,
Miyamoto Takuya,
Watanabe Tetsu,
Kubota Isao
Publication year - 2015
Publication title -
journal of arrhythmia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 21
eISSN - 1883-2148
pISSN - 1880-4276
DOI - 10.1016/j.joa.2015.02.003
Subject(s) - medicine , catheter ablation , atrial fibrillation , placebo , anesthesia , ablation , adverse effect , radiofrequency ablation , odds ratio , cardiology , confidence interval , alternative medicine , pathology
Background Immediate recurrence of atrial fibrillation (AF) after radiofrequency (RF) catheter ablation is commonly observed within 3 d after the procedure. The mechanism and pharmacological management of immediate AF recurrence remain unclear. Methods A total of 50 consecutive patients with paroxysmal AF were randomized to receive either low‐dose landiolol (landiolol group) or a placebo (placebo group). In the landiolol group, intravenous landiolol (0.5 μg kg −1 min −1 ) was administered for 3 d after AF ablation. Results No serious adverse event associated with RF catheter ablation or landiolol administration was observed. The prevalence of immediate AF recurrence (≤3 d after RF catheter ablation) was significantly lower in the landiolol group than in the placebo group (16% vs. 48%, p =0.015). Although the postprocedural change in heart rate was significantly lower in the landiolol group compared to that in the placebo group, the changes in blood pressure and body temperature were not different between the two groups. Multiple logistic regression analysis revealed that landiolol treatment was the only independent predictor of immediate AF recurrence after ablation (odds ratio: 0.180; 95% confidence interval: 0.044–0.729; p =0.016). Conclusions Prophylactic administration of low‐dose landiolol after AF ablation may be effective and safe for preventing immediate AF recurrence within 3 d after AF ablation.