Open AccessMonophasic action potential duration alternans after abrupt shortening of the cardiac cycle in humans
Author(s) -
Sonoda Kazumasa,
Watanabe Ichiro,
Okumura Yasuo,
Sasaki Naoko,
Kogawa Rikitake,
Takahashi Keiko,
Mano Hiroaki,
Kofune Masayoshi,
Ohkubo Kimie,
Nakai Toshiko,
Kunimoto Satoshi,
Hirayama Atsushi
Publication year - 2014
Publication title -
journal of arrhythmia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 21
eISSN - 1883-2148
pISSN - 1880-4276
DOI - 10.1016/j.joa.2013.06.005
Subject(s) - medicine , cardiology , endocardium , defibrillation , ventricular fibrillation , atrial action potential , atrial fibrillation , action (physics) , cardiac action potential , duration (music) , repolarization , electrophysiology , physics , literature , quantum mechanics , art
Background Action potential alternans may be important in causing ventricular arrhythmias. Methods and results We recorded monophasic action potentials from the right ventricular endocardium in patients with persistent atrial fibrillation who underwent internal atrial defibrillation during rapid ventricular pacing. In 3 of 45 patients, monophasic action potential duration alternans was observed at a pacing cycle length ≤350 ms. Conclusion Action potential alternans is not a rare phenomenon (6.6%) in humans.