Open AccessDrug‐induced Brugada syndrome
Author(s) -
Minoura Yoshino,
Kobayashi Youichi,
Antzelevitch Charles
Publication year - 2013
Publication title -
journal of arrhythmia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 21
eISSN - 1883-2148
pISSN - 1880-4276
DOI - 10.1016/j.joa.2013.02.002
Subject(s) - medicine , brugada syndrome , sudden cardiac death , drug , incidence (geometry) , cardiology , drug class , pharmacology , physics , optics
Brugada syndrome (BrS) is an inherited cardiac disorder that is associated with an electrocardiogram pattern of ST segment elevation on right precordial leads and a high incidence of sudden death. Diagnosis requires documentation of a coved‐type ST segment that occurs spontaneously or in the presence of a class IA or IC antiarrhythmic agent. A wide variety of other drugs, including antianginals, antidepressants, antipsychotics, and antihistamines, have been reported to unmask or induce the electrocardiographic and arrhythmic manifestations of BrS. This review focuses on drug‐induced BrS phenotypes, prevalence, and underlying mechanisms.