Open AccessEpidemiology of Brugada syndrome in Japan and rest of the world
Author(s) -
Kamakura Shiro
Publication year - 2013
Publication title -
journal of arrhythmia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 21
eISSN - 1883-2148
pISSN - 1880-4276
DOI - 10.1016/j.joa.2013.01.004
Subject(s) - brugada syndrome , medicine , epidemiology , incidence (geometry) , ventricular fibrillation , disease , cardiology , ethnic group , sudden cardiac death , sudden death , cause of death , pediatrics , physics , sociology , anthropology , optics
Brugada syndrome is an inherited disease that causes sudden death because of ventricular fibrillation. Its prevalence is approximately 0.15% in adults and 0.005% in children in Asia, and less than 0.02% in the West. The reason for the higher prevalence in Asia is likely ethnic‐specific polymorphisms modulating the activity of the primary disease‐causing mutation. In Japan, the incidence of Brugada‐pattern electrocardiogram (ECG) is 14.2 per 100,000 person‐years. Data from multicenter registries indicate that its frequency in men with Brugada syndrome is higher in Japanese patients (94–96%) than in Caucasian patients (72–80%). Healthy individuals with Brugada‐type ECG have a favorable prognosis with an annual death rate of less than 0.5%.