Open AccessBrugada syndrome in the presence of coronary artery disease
Author(s) -
Ohkubo Kimie,
Watanabe Ichiro,
Okumura Yasuo,
Kofune Masayoshi,
Nagashima Koichi,
Mano Hiroaki,
Sonoda Kazumasa,
Kogawa Rikitake,
Sasaki Naoko,
Nakai Toshiko,
Kunimoto Satoshi,
Kasamaki Yuji,
Hirayama Atsushi
Publication year - 2013
Publication title -
journal of arrhythmia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 21
eISSN - 1883-2148
pISSN - 1880-4276
DOI - 10.1016/j.joa.2012.09.008
Subject(s) - medicine , brugada syndrome , cardiology , coronary artery disease , asymptomatic , ventricular fibrillation , incidence (geometry) , sudden cardiac death , physics , optics
Background Brugada‐type ECG changes have been described in association with various cardiac disease states including electrolyte abnormalities, myocardial pathologies, and mechanical cardiac abnormalities as well as drug therapies with particular medications. Such potential confounding factors make it difficult to diagnose Brugada syndrome on the basis of standard guidelines. Methods To investigate the incidence of significant coronary artery disease in patients with Brugada‐type ECG, coronary angiography was performed in 55 patients with Brugada‐type ECGs. Results Five of the 55 patients (9%) had significant coronary artery stenosis, and 3 out of these 5 were asymptomatic. Patients with coronary artery disease were older than in those without coronary artery disease (59.4±7.2 years vs. 49.0±13.8 years, P =0.03). An electrophysiological study was performed in 4 of the 5 patients, and ventricular fibrillation was induced in all 4. Conclusions We conclude that patients with Brugada‐type ECGs should be evaluated for coronary artery disease, and this is especially important for patients in whom age could be a risk factor for the disease.