Open AccessMarkedly reduced ventricular arrhythmia during the peripartum period in a pregnant woman with Andersen‐Tawil syndrome
Author(s) -
Kamiya Chizuko A.,
Shimizu Wataru,
Kabayashi Yoshinari,
Miyoshi Takekazu,
Horiuchi Chinami,
Umekawa Takashi,
Yamanaka Kaoru,
Neki Reiko,
Katsuragi Shinji,
Yoshimatsu Jun,
Ikeda Tomoaki
Publication year - 2012
Publication title -
journal of arrhythmia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 21
eISSN - 1883-2148
pISSN - 1880-4276
DOI - 10.1016/j.joa.2012.08.002
Subject(s) - medicine , periodic paralysis , pregnancy , cardiology , long qt syndrome , ventricular tachycardia , qt interval , paralysis , surgery , genetics , biology
Andersen‐Tawil syndrome (ATS), also known as long QT syndrome type 7, is a rare autosomal dominant disease caused by a KCNJ2 mutation. The characteristic triad of ATS is periodic paralysis, dysmorphic features, and ventricular arrhythmia. We describe a case of a woman with Andersen‐Tawil syndrome and a history of syncope whose pregnancy was complicated with frequent premature ventricular contractions (PVCs) and nonsustained ventricular tachycardia (NSVT). Her PVCs and NSVT were significantly decreased during the peripartum period, especially during labor. We treated her with beta‐blockers throughout her pregnancy, and she experienced no complications. Although the mechanism underlying the decreased PVCs and NSVT in pregnancy has not been elucidated, women with ATS may have less arrhythmic event risk during pregnancy.