Open AccessImpact of CYP1A1, GSTP1 and XRCC1 genes polymorphisms on toxicity and response to chemotherapy in childhood acute lymphoblastic leukemia
Author(s) -
Asmaa Abobakr,
Ghada I. Mossallam,
Nevin El Azhary,
Hanafy Hafez,
Ragia H. Badawy
Publication year - 2017
Publication title -
journal of egyptian national cancer institute/journal of the egyptian national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.398
H-Index - 22
eISSN - 2589-0409
pISSN - 1110-0362
DOI - 10.1016/j.jnci.2017.07.002
Subject(s) - xrcc1 , gstp1 , single nucleotide polymorphism , medicine , genotype , oncology , dna repair , genetics , gene , biology
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. The interindividual genetic variations in drug metabolizing enzymes and DNA repair genes influence the efficacy and toxicity of numerous chemotherapeutic drugs affecting the treatment outcome.