Open AccessBreaking the ritual metabolic cycle in order to save acetyl CoA: A potential role for mitochondrial humanin in T2 bladder cancer aggressiveness
Author(s) -
Nesreen Nabil Omar,
Reham Tash,
Youssef Shoukry,
Karim Omar ElSaeed
Publication year - 2017
Publication title -
journal of egyptian national cancer institute/journal of the egyptian national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.398
H-Index - 22
eISSN - 2589-0409
pISSN - 1110-0362
DOI - 10.1016/j.jnci.2017.04.001
Subject(s) - citric acid cycle , glycolysis , apoptosis , mitochondrion , cancer , medicine , mitochondrial dna , cancer research , microbiology and biotechnology , metabolism , biology , biochemistry , gene
Cancer cells may exhibit outsourcing of their high energy need in order to avoid the intrinsic mitochondrial apoptosis. Reduced mitochondrial respiration and accumulation of mitochondrial genome mutations are among metabolic transformations in this regard. Mitochondrial humanin (MT-RNR2) is a small peptide with anti-apoptotic activities attributed to binding some pro-apoptotic proteins.