Quantitative analysis of plasma cell-free DNA and its DNA integrity in patients with metastatic prostate cancer using ALU sequence | Zendy

Amal Fawzy | Zendy; Karima Mohammad Sweify | Zendy; Hany ElFayoumy | Zendy; Nagwa Nofal | Zendy

Open Access

Quantitative analysis of plasma cell-free DNA and its DNA integrity in patients with metastatic prostate cancer using ALU sequence

Author(s) -

Amal Fawzy,

Karima Mohammad Sweify,

Hany ElFayoumy,

Nagwa Nofal

Publication year - 2016

Publication title -

journal of the egyptian national cancer institute

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.398

H-Index - 22

eISSN - 2589-0409

pISSN - 1110-0362

DOI - 10.1016/j.jnci.2016.08.003

Subject(s) - medicine , prostate cancer , dna , sequence (biology) , dna sequencing , cell free fetal dna , cancer research , oncology , computational biology , cancer , genetics , biology , pregnancy , prenatal diagnosis , fetus

Prostate cancer (PC) is the most common cancer affecting men, it accounts for 29% of all male cancer and 11% of all male cancer related death. DNA is normally released from an apoptotic source which generates small fragments of cell-free DNA, whereas cancer patients have cell-free circulating DNA that originated from necrosis, autophagy, or mitotic catastrophe, which produce large fragments.

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