Open AccessQuantitative analysis of plasma cell-free DNA and its DNA integrity in patients with metastatic prostate cancer using ALU sequence
Author(s) -
Amal Fawzy,
Karima Mohammad Sweify,
Hany ElFayoumy,
Nagwa Nofal
Publication year - 2016
Publication title -
journal of egyptian national cancer institute/journal of the egyptian national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.398
H-Index - 22
eISSN - 2589-0409
pISSN - 1110-0362
DOI - 10.1016/j.jnci.2016.08.003
Subject(s) - medicine , prostate cancer , dna , sequence (biology) , dna sequencing , cell free fetal dna , cancer research , oncology , computational biology , cancer , genetics , biology , pregnancy , prenatal diagnosis , fetus
Prostate cancer (PC) is the most common cancer affecting men, it accounts for 29% of all male cancer and 11% of all male cancer related death. DNA is normally released from an apoptotic source which generates small fragments of cell-free DNA, whereas cancer patients have cell-free circulating DNA that originated from necrosis, autophagy, or mitotic catastrophe, which produce large fragments.