Open AccessAdhesion molecules expression in CLL: Potential impact on clinical and hematological parameters
Author(s) -
Azza M. Kamel,
Nahla El-Sharkawy,
Randa A. Osman,
Eman K. Abd El-Fattah,
Essam H. Elnoshokaty,
Thoraya Abd El-Hamid,
Eman Z. Kandeel
Publication year - 2016
Publication title -
journal of egyptian national cancer institute/journal of the egyptian national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.398
H-Index - 22
eISSN - 2589-0409
pISSN - 1110-0362
DOI - 10.1016/j.jnci.2016.01.003
Subject(s) - medicine , cell adhesion molecule , expression (computer science) , chronic lymphocytic leukemia , cancer research , immunology , leukemia , computer science , programming language
B-cell chronic lymphocytic leukemia (CLL) is marked by the accumulation of CD5+ B lymphocytes within the blood, bone marrow (BM), and secondary lymphoid tissues. Abnormalities in the expression and function of cell adhesion molecules may account for the patterns of intra-nodal growth and hematogenous spread of the malignant cells. Chemokines and integrin-mediated adhesion and trans-endothelial migration (TEM) are central aspects in trafficking and retention of hematopoietic cells in the BM and lymphoid organs.