z-logo
open-access-imgOpen Access
Adhesion molecules expression in CLL: Potential impact on clinical and hematological parameters
Author(s) -
Azza M. Kamel,
Nahla El-Sharkawy,
Randa A. Osman,
Eman K. Abd El-Fattah,
Essam H. Elnoshokaty,
Thoraya Abd El-Hamid,
Eman Z. Kandeel
Publication year - 2016
Publication title -
journal of egyptian national cancer institute/journal of the egyptian national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.398
H-Index - 22
eISSN - 2589-0409
pISSN - 1110-0362
DOI - 10.1016/j.jnci.2016.01.003
Subject(s) - medicine , cell adhesion molecule , expression (computer science) , chronic lymphocytic leukemia , cancer research , immunology , leukemia , computer science , programming language
B-cell chronic lymphocytic leukemia (CLL) is marked by the accumulation of CD5+ B lymphocytes within the blood, bone marrow (BM), and secondary lymphoid tissues. Abnormalities in the expression and function of cell adhesion molecules may account for the patterns of intra-nodal growth and hematogenous spread of the malignant cells. Chemokines and integrin-mediated adhesion and trans-endothelial migration (TEM) are central aspects in trafficking and retention of hematopoietic cells in the BM and lymphoid organs.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here