Open AccessRole of immunohistochemistry and fluorescence in-situ hybridization (FISH) in the diagnosis of spindle and round cell tumors of the kidney
Author(s) -
Mahmoud Abbas,
Maximilian Ernst Dämmrich,
Peter Braubach,
Mario W. Kramer,
Viktor Grünwald,
Axel S. Merseburger,
Thomas Herrmann,
Jan Ulrich Becker,
Hans-Heinrich Kreipe
Publication year - 2015
Publication title -
journal of egyptian national cancer institute/journal of the egyptian national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.398
H-Index - 22
eISSN - 2589-0409
pISSN - 1110-0362
DOI - 10.1016/j.jnci.2015.04.005
Subject(s) - medicine , pathology , immunohistochemistry , synovial sarcoma , fluorescence in situ hybridization , renal cell carcinoma , sarcoma , biology , biochemistry , chromosome , gene
Spindle cell/mesenchymal tumors of the kidney are rare. The diagnosis is supported mainly by the application of ancillary techniques such as immunohistochemistry (IH) and in-situ hybridization (FISH). An accurate diagnosis is essential because early management by complete resection and adjuvant chemotherapy improves the prognosis dramatically. Synovial sarcoma and primitive neuroectodermal tumor/Ewing sarcoma are infrequent malignancies which usually present in soft tissues but rarely in the kidney. The challenge for the pathologists is to histologically differentiate between different types of sarcomas such as PNET/Ewing's sarcoma, sarcomatous dedifferentiated renal cell carcinoma, metastasis, non-Hodgkin's lymphoma, nephroblastoma and angiomyolipoma.