Open AccessPrimary mucinous adenocarcinoma of the renal pelvis with carcinoma in situ in the ureter
Author(s) -
Mahmoud Abbas,
Mario W. Kramer,
Tilmann Spieker,
Thomas R.W. Herrman,
Axel S. Merseburger,
KlausMichael Müller,
M. Kuczyk,
Jan Ulrich Becker,
Hans-Heinrich Kreipe
Publication year - 2014
Publication title -
journal of egyptian national cancer institute/journal of the egyptian national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.398
H-Index - 22
eISSN - 2589-0409
pISSN - 1110-0362
DOI - 10.1016/j.jnci.2013.11.002
Subject(s) - renal pelvis , ureter , adenocarcinoma , pathology , medicine , carcinoma in situ , mucinous carcinoma , papillary adenocarcinoma , carcinoma , pathological , urology , cancer
Primary epithelial tumor of the renal pelvis is rare and only 100 cases are reported in the literature [1]. Histological examination of the tumor showed glands, cysts, and papillae lined by pseudostratified columnar epithelium with hyperchromatic nuclei. Scattered signet ring-type cells were also seen floating in large pools of extracellular mucin. Sections from the ureter showed a component of adenocarcinoma in situ. No invasive tumor was identified in ureteric tissue. One case was reported with carcinoma in situ of the ureter (2). Immunohistochemically: The tumor showed positivity for CK7, CK20, CK8/18, GATA-3, MSH-2, MSH-6, MLH-1, Ber-EP4, and S-100-P with focal positivity for CDX-2, weak positivity for PMS-2 and negativity in TTF-1 and Her-2. Molecular pathological analysis revealed microsatellite stability and without mutation in K-ras-gene. Thus, a diagnosis of mucinous adenocarcinoma of the renal pelvis with in situ adenocarcinoma of the ureter was made.