Open AccessPrognostic value of IDH1 mutations identified with PCR-RFLP assay in acute myeloid leukemia patients
Author(s) -
Ghada M. El-Sayed,
Hanan R. Nassar,
Amr Zaher,
Essam H. Elnoshokaty,
Manar M. Moneer
Publication year - 2014
Publication title -
journal of egyptian national cancer institute/journal of the egyptian national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.398
H-Index - 22
eISSN - 2589-0409
pISSN - 1110-0362
DOI - 10.1016/j.jnci.2013.11.001
Subject(s) - idh1 , myeloid leukemia , isocitrate dehydrogenase , cold pcr , restriction fragment length polymorphism , medicine , polymerase chain reaction , restriction enzyme , gene mutation , somatic cell , leukemia , mutation , gene , cancer research , biology , genetics , point mutation , enzyme , biochemistry
Somatic mutations in isocitrate dehydrogenase 1 (IDH1) gene occur frequently in primary brain tumors. Recently theses mutations were demonstrated in acute myeloid leukemia (AML). So far, assessment of these mutations relied on the DNA sequencing technique.