Open AccessDJ-1 and androgen receptor immunohistochemical expression in prostatic carcinoma: A possible role in carcinogenesis
Author(s) -
Wesam M. Osman,
Rasha M. Abd El Atti,
Hoda H Abou Gabal
Publication year - 2013
Publication title -
journal of egyptian national cancer institute/journal of the egyptian national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.398
H-Index - 22
eISSN - 2589-0409
pISSN - 1110-0362
DOI - 10.1016/j.jnci.2013.08.001
Subject(s) - medicine , immunostaining , androgen receptor , immunohistochemistry , hyperplasia , prostate cancer , prostate , carcinogenesis , carcinoma , pathology , cancer , pca3 , adenocarcinoma , cancer research
Androgen plays a fundamental role in the growth and differentiation of prostate. Androgen receptor (AR) expression may represent a potential marker of prognosis in prostate cancer. However, there have been variable results regarding its ability to predict clinical progression. Despite the oncogenic properties of DJ-1, its significance in prostate cancer development and progression is not well understood. This research shed some light on the possible role of immunohistochemical expression of DJ-1 in clinically localized prostatic carcinoma in relation to the established role of AR and other clinicopathologic parameters.