Open AccessEffectiveness of rapid multiplex polymerase chain reaction for early diagnosis and treatment of pertussis
Author(s) -
Se Chang Oh,
Soo Min Park,
Jian Hur,
Eun Young Choi,
Hyun Jung Jin,
Yu Kyung Kim,
Jong Ho Lee,
Ji Young Ahn,
Jae Min Lee
Publication year - 2020
Publication title -
journal of microbiology immunology and infection
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.223
H-Index - 57
eISSN - 1995-9133
pISSN - 1684-1182
DOI - 10.1016/j.jmii.2020.05.012
Subject(s) - medicine , bordetella pertussis , whooping cough , medical record , incidence (geometry) , pediatrics , outbreak , multiplex polymerase chain reaction , polymerase chain reaction , immunology , vaccination , virology , biochemistry , chemistry , genetics , physics , bacteria , gene , optics , biology
Pertussis, is an infectious respiratory disease caused by Bordetella pertussis. The incidence of pertussis has been increasing in South Korea to due to waning vaccine-induced immunity. Culture has a low sensitivity and a long turnaround time (TAT). Recently, a rapid multi-polymerase chain reaction (mPCR) test with a TAT of about 1 h was developed for the detection of respiratory pathogens (17 viruses and three bacteria), including B. pertussis. This study aimed to investigate the effectiveness of mPCR for early diagnosis and treatment of pertussis.
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