Diagnostic performance of rapid antigen test for COVID-19 and the effect of viral load, sampling time, subject’s clinical and laboratory parameters on test accuracy | Zendy

Rania Amer | Zendy; Mohamed Samir | Zendy; Osama Gaber | Zendy; Nahawand A. El-Deeb | Zendy; Ahmed Abdelmoaty | Zendy; Alshymaa A. Ahmed | Zendy; Walaa Samy | Zendy; Amal Atta | Zendy; Mohammad Walaa | Zendy; Reham H. Anis | Zendy

Open Access

Diagnostic performance of rapid antigen test for COVID-19 and the effect of viral load, sampling time, subject’s clinical and laboratory parameters on test accuracy

Author(s) -

Rania Amer,

Mohamed Samir,

Osama Gaber,

Nahawand A. El-Deeb,

Ahmed Abdelmoaty,

Alshymaa A. Ahmed,

Walaa Samy,

Amal Atta,

Mohammad Walaa,

Reham H. Anis

Publication year - 2021

Publication title -

journal of infection and public health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.983

H-Index - 35

eISSN - 1876-035X

pISSN - 1876-0341

DOI - 10.1016/j.jiph.2021.06.002

Subject(s) - receiver operating characteristic , covid-19 , medicine , viral load , pandemic , test (biology) , diagnostic accuracy , sampling (signal processing) , support vector machine , statistics , pathology , virology , immunology , disease , machine learning , computer science , human immunodeficiency virus (hiv) , biology , mathematics , paleontology , infectious disease (medical specialty) , filter (signal processing) , computer vision

Egypt was among the first 10 countries in Africa that experienced COVID-19 cases. The sudden surge in the number of cases is overwhelming the capacity of the national healthcare system, particularly in developing countries. Central to the containment of the ongoing pandemic is the availability of rapid and accurate diagnostic tests that could pinpoint patients at early disease stages. In the current study, we aimed to (1) Evaluate the diagnostic performance of the rapid antigen test (RAT) "Standard™ Q COVID-19 Ag" against reverse transcriptase quantitative real-time PCR (RT-qPCR) in eighty-three swabs collected from COVID-19 suspected individuals showing various demographic features, clinical and radiological findings. (2) Test whether measuring laboratory parameters in participant's blood would enhance the predictive accuracy of RAT. (3) Identify the most important features that determine the results of both RAT and RT-qPCR.

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