Cytokine storm of a different flavour: The different cytokine signature of SARS-CoV-2, the cause of COVID-19, from the original SARS outbreak | Zendy

Daniel O. Griffin | Zendy; Alexandra Jensen | Zendy; Mushmoom Khan | Zendy; Jessica Chin | Zendy; Kelly Chin | Zendy; Jennifer Saad | Zendy; Ryan Parnell | Zendy; Christopher Awwad | Zendy; Darshan P. Patel | Zendy

Open Access

Cytokine storm of a different flavour: The different cytokine signature of SARS-CoV-2, the cause of COVID-19, from the original SARS outbreak

Author(s) -

Daniel O. Griffin,

Alexandra Jensen,

Mushmoom Khan,

Jessica Chin,

Kelly Chin,

Jennifer Saad,

Ryan Parnell,

Christopher Awwad,

Darshan P. Patel

Publication year - 2020

Publication title -

journal of global antimicrobial resistance

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.917

H-Index - 26

eISSN - 2213-7173

pISSN - 2213-7165

DOI - 10.1016/j.jgar.2020.11.005

Subject(s) - cytokine storm , cytokine , outbreak , medicine , covid-19 , interleukin , immunology , virology , coronavirus , disease , infectious disease (medical specialty) , pathology

Here we present a case series of three patients with COVID-19 (coronavirus disease 2019) who had a cytokine panel that revealed elevation of interleukin-6 (IL-6) but normal levels of interleukin-10 (IL-10), interferon-gamma (INF-γ) and interleukin-8 (IL-8), in contrast to the cytokine signature described in severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). We also documented evidence of a compromised T-cell IFN-γ response in two of these patients.

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