Circulating B-type natriuretic peptide levels and its correlation to Qp/Qs ratio among children undergoing congenital heart surgery | Zendy

Ahmed Farouk | Zendy; Magdy Algowhary | Zendy; Mohammed H. Hassan | Zendy; Ahmed Elminshawy | Zendy; Mohamed Abdel-Bary | Zendy; Hatem H Maghraby | Zendy; Tahia H. Saleem | Zendy

Open Access

Circulating B-type natriuretic peptide levels and its correlation to Qp/Qs ratio among children undergoing congenital heart surgery

Author(s) -

Ahmed Farouk,

Magdy Algowhary,

Mohammed H. Hassan,

Ahmed Elminshawy,

Mohamed Abdel-Bary,

Hatem H Maghraby,

Tahia H. Saleem

Publication year - 2017

Publication title -

journal of the egyptian society of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

eISSN - 2524-1745

pISSN - 1110-578X

DOI - 10.1016/j.jescts.2017.03.002

Subject(s) - medicine , natriuretic peptide , cardiac surgery , heart disease , cardiology , brain natriuretic peptide , prospective cohort study , positive correlation , cardiac catheterization , plasma levels , heart failure

Background: Data about different types of cardiac biomarkers is still limited in children with congenital heart disease (CHD) when compared to that in adults. We evaluated the circulating levels of B-type natriuretic peptide (BNP) in children with different types of CHD and correlated the levels with the calculated Qp/Qs ratio and the outcome of the congenital heart surgery.Methods: A prospective cross sectional- case control study was carried out on 43 pediatric patients with different types of CHD, undergoing elective cardiac surgery for shunt closure, admitted at the department of Cardiothoracic surgery-Faculty of Medicine- Assiut and Qena University hospitals. This was in addition to 17 healthy controls. All patients were diagnosed by echocardiography and cardiac catheterization. Qp/Qs ratio was calculated for every included patient. ELISA assays of plasma levels of BNP in the study groups were done.Results: The following findings were obtained: significant higher plasma levels of BNP among CHD children when compared with the control group (p < 0.001). Significant higher Qp/Qs ratio in children having ASD or VSD versus those had PDA (p < 0.001). Significant positive correlation between plasma BNP and Qp/Qs ratio among CHD children (r = 0.541, p < 0.001). Cut-off values for plasma BNP and Qp/Qs ratio in predicting the negative outcome were >55 pg/ml and >2.36 respectively with 100% sensitivity and 97.5% specificity.Conclusions: BNP could be considered as a valuable cardiac marker in CHD and could be a reliable marker for predicting the negative outcome of the congenital heart surgery when combined with Qp/Qs ratio

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