Open AccessCirculating B-type natriuretic peptide levels and its correlation to Qp/Qs ratio among children undergoing congenital heart surgery
Author(s) -
Ahmed Farouk,
Magdy Algowhary,
Mohammed H. Hassan,
Ahmed Elminshawy,
Mohamed Abdel-Bary,
Hatem H Maghraby,
Tahia H. Saleem
Publication year - 2017
Publication title -
journal of the egyptian society of cardio-thoracic surgery
Language(s) - English
Resource type - Journals
eISSN - 2524-1745
pISSN - 1110-578X
DOI - 10.1016/j.jescts.2017.03.002
Subject(s) - natriuretic peptide , medicine , cardiology , correlation , heart failure , mathematics , geometry
Background: Data about different types of cardiac biomarkers is still limited in children with congenital heart disease (CHD) when compared to that in adults. We evaluated the circulating levels of B-type natriuretic peptide (BNP) in children with different types of CHD and correlated the levels with the calculated Qp/Qs ratio and the outcome of the congenital heart surgery.Methods: A prospective cross sectional- case control study was carried out on 43 pediatric patients with different types of CHD, undergoing elective cardiac surgery for shunt closure, admitted at the department of Cardiothoracic surgery-Faculty of Medicine- Assiut and Qena University hospitals. This was in addition to 17 healthy controls. All patients were diagnosed by echocardiography and cardiac catheterization. Qp/Qs ratio was calculated for every included patient. ELISA assays of plasma levels of BNP in the study groups were done.Results: The following findings were obtained: significant higher plasma levels of BNP among CHD children when compared with the control group (p < 0.001). Significant higher Qp/Qs ratio in children having ASD or VSD versus those had PDA (p < 0.001). Significant positive correlation between plasma BNP and Qp/Qs ratio among CHD children (r = 0.541, p < 0.001). Cut-off values for plasma BNP and Qp/Qs ratio in predicting the negative outcome were >55 pg/ml and >2.36 respectively with 100% sensitivity and 97.5% specificity.Conclusions: BNP could be considered as a valuable cardiac marker in CHD and could be a reliable marker for predicting the negative outcome of the congenital heart surgery when combined with Qp/Qs ratio