Open AccessCutaneous Rosai-Dorfman disease: A separate clinical entity
Author(s) -
Tiffany Hinojosa,
Elmira Ramos,
Daniel Lewis,
Laurent del Angel,
Ramya Vangipuram,
Andrew J. Peranteau,
Stephen K. Tyring
Publication year - 2017
Publication title -
journal of dermatology and dermatologic surgery
Language(s) - English
Resource type - Journals
eISSN - 2352-2429
pISSN - 2352-2410
DOI - 10.1016/j.jdds.2017.06.005
Subject(s) - rosai–dorfman disease , medicine , etiology , disease , histiocytosis , cervical lymphadenopathy , dermatology , sinus histiocytosis with massive lymphadenopathy , emperipolesis , pathology , histiocyte , rare disease , cervical lymph nodes , lymph , cancer , metastasis
Rosai-Dorfman disease is a benign, self-limited non-Langerhans cell histiocytosis of unknown etiology. Its most common clinical feature is extraordinary massive painless cervical lymphadenopathy. This entity may be limited to the lymph nodes; however, more than 40% of patients have extranodal involvement, with the skin being the most frequently affected site. Cutaneous disease without the presence of lymphadenopathy is extremely rare but has been reported. We report the intriguing case of exclusively cutaneous Rosai-Dorfman disease in an 80-year-old African-American woman