Open AccessEpidermolysis bullosa pruriginosa a clinico-pathological study in an index case, highlighting its affliction in 11 of 27 member of the family
Author(s) -
Manisha Nijhawan,
Savita Agarwal,
Shivi Nijhawan,
Rakesh Jhangra,
Pallavi Goel,
Virendra Sehgal
Publication year - 2017
Publication title -
journal of dermatology and dermatologic surgery
Language(s) - English
Resource type - Journals
eISSN - 2352-2429
pISSN - 2352-2410
DOI - 10.1016/j.jdds.2017.04.002
Subject(s) - medicine , dermatology , epidermolysis bullosa , family member , pathological , acanthosis , hyperkeratosis , epidermis (zoology) , pathology , blisters , immunology , anatomy , family medicine
Epidermolysis bullosa pruriginosa, a rare variant of dominant inheritance pattern, characterized by itchy, papules and/or nodules coalescing to form plaque(s), studded by blisters, is describe in a young man an index case. In all 12 afflicted individuals of the 27 family members was interesting, the diagnosis of which was made by its morphology and inflammatory changes in the epidermis, comprising hyperkeratosis, moderate acanthosis, presence of inflammatory cells, and above all inflammatory cell containing sub-epidermal cleavage or cleft