Open AccessPsoriasis induced by Interferon alfa-2a and ribavirin in a patient followed for hepatitis C
Author(s) -
N. Amraoui,
S. Gallouj,
N. Oubelkacem,
W. Bono,
F.Z. Mernissi
Publication year - 2015
Publication title -
journal of dermatology and dermatologic surgery
Language(s) - English
Resource type - Journals
eISSN - 2352-2429
pISSN - 2352-2410
DOI - 10.1016/j.jdds.2015.01.002
Subject(s) - medicine , ribavirin , psoriasis , chronic hepatitis , betamethasone dipropionate , dermatology , pegylated interferon , hepatitis c , interferon , hepatitis , betamethasone , interferon alfa , hepatitis c virus , gastroenterology , alpha interferon , immunology , virus
In patients suffering from chronic hepatitis C, Interferon (INF) associated with ribavirin therapy can induce various side effects involving the skin. Our case describes the clinical course of a patient with chronic hepatitis C treated with pegylated α2 INF plus ribavirin. After 6weeks of therapy he developed psoriasis. However, given the progressive improvement of his transaminase levels and viral load decrease, we continued the protocol of the treatment and we started topical calcipotriol/betamethasone dipropionate ointment for psoriasic lesions. After this, the psoriasis improved in a slow but comprehensive manner. This paper suggests that physicians should keep in mind the possibility of the onset of psoriasis as a side effect of INF treatment for chronic hepatitis C