Open AccessHemophagocytic syndrome and acute pancreatitis in acute systemic lupus erythematosus
Author(s) -
Bushra Alblewi,
Iqbal A. Bukhari,
Manal Hasan,
Abdulaziz Alzahani,
Raed Bukhari,
Layla Bashawri,
Muhammad Al Shawarby
Publication year - 2014
Publication title -
journal of dermatology and dermatologic surgery
Language(s) - English
Resource type - Journals
eISSN - 2352-2429
pISSN - 2352-2410
DOI - 10.1016/j.jdds.2014.03.004
Subject(s) - hemophagocytosis , medicine , hepatosplenomegaly , acute pancreatitis , histiocyte , macrophage activation syndrome , mononuclear phagocyte system , pathogenesis , immunology , macrophage , pancreatitis , pathology , bone marrow , pancytopenia , disease , biochemistry , chemistry , arthritis , in vitro
Hemophagocytic syndrome (HPS) is characterized by the activation of histiocytes with prominent hemophagocytosis in bone marrow and other reticuloendothelial systems. It has two forms: primary and secondary. The precise pathogenesis of HPS is unclear but a dysregulation of macrophage–lymphocyte interactions with subsequent increases in the levels of both T-cell-derived and macrophage-derived cytokines has been suggested. Cardinal symptoms of HPS are prolonged high fever, hepatosplenomegaly, cytopenias, lymphadenopathy and neurological symptoms. In this report, we present a case Systemic Lupus Erythematosus associated with HPS and acute pancreatitis