Open AccessPure mucinous carcinoma of breast cancer in 56 Tunisian women
Author(s) -
Maher Slimane,
Jamel Ben Hassouna,
Selma Gadria,
B Laamouri,
Nurul Ain Mohammad Hamdi,
Amor Gamoudi,
M Hechiche,
Khaled Rahal
Publication year - 2017
Publication title -
journal of cancer research and practice
Language(s) - English
Resource type - Journals
eISSN - 2589-0425
pISSN - 2311-3006
DOI - 10.1016/j.jcrpr.2017.03.002
Subject(s) - medicine , breast cancer , mucinous carcinoma , malignancy , oncology , univariate analysis , retrospective cohort study , stage (stratigraphy) , mastectomy , pathological , cancer , gynecology , adenocarcinoma , multivariate analysis , paleontology , biology
Background: Pure mucinous carcinoma breast cancer (PMBC) is a relatively rare subtype cancer of breast malignancy and associated with favorable prognosis. This retrospective study aims to investigate clinical, pathological features and clinical long-term outcomes.Methods: A retrospective review of 56 patients' files with pure mucinous breast cancer was performed. We evaluated the clinic-pathologic characteristics and survival status.Results: The mean age was 59 years. 37 patients underwent modified radical mastectomy; 14 underwent breast-conserving surgery. The 5-years overall survival (OS) and disease free survival (DFS) rates were respectively 75,3% and 74%. According to univariate analysis for OS, age (p = 0,049), menopausal status (p = 0,024), clinical T stage (p = 0,037), N stage (p = 0,002) and pathological T stage (p = 0,033) were statistically significant factors for survival.The DFS was better in postmenopausal women (p = 0,02), histological tumor size smaller than 20 mm (p = 0,024), and negative lymph nodes (p = 0,049).Conclusion: Pure mucinous breast cancer has a favorable prognosis and is characterized by lower tumor grade, higher hormone receptor expression and lower incidence of nodal involvement. Thanks to its good prognosis, this subtype of cancer should be treated less aggressively than invasive ductal carcinoma