Augmentation of Tissue Perfusion in Patients With Peripheral Artery Disease Using Microbubble Cavitation | Zendy

O’Neil Mason | Zendy; Brian P. Davidson | Zendy; Paul S. Sheeran | Zendy; Matthew Muller | Zendy; James Hodovan | Zendy; Jonathan Sutton | Zendy; Jeffry Powers | Zendy; Jonathan R. Lindner | Zendy

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Augmentation of Tissue Perfusion in Patients With Peripheral Artery Disease Using Microbubble Cavitation

Author(s) -

O’Neil Mason,

Brian P. Davidson,

Paul S. Sheeran,

Matthew Muller,

James Hodovan,

Jonathan Sutton,

Jeffry Powers,

Jonathan R. Lindner

Publication year - 2019

Publication title -

jacc. cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.79

H-Index - 120

eISSN - 1936-878X

pISSN - 1876-7591

DOI - 10.1016/j.jcmg.2019.06.012

Subject(s) - perfusion , microbubbles , in vivo , ultrasound , medicine , hindlimb , peripheral , vasodilation , biomedical engineering , blood flow , limb perfusion , femoral artery , nuclear medicine , cardiology , radiology , biology , microbiology and biotechnology

The authors investigated ideal acoustic conditions on a clinical scanner custom-programmed for ultrasound (US) cavitation-mediated flow augmentation in preclinical models. We then applied these conditions in a first-in-human study to test the hypothesis that contrast US can increase limb perfusion in normal subjects and patients with peripheral artery disease (PAD).

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