Molecular Imaging of Apoptosis in Ischemia Reperfusion Injury With Radiolabeled Duramycin Targeting Phosphatidylethanolamine | Zendy

Hideki Kawai | Zendy; Farhan Chaudhry | Zendy; Aditya C. Shekhar | Zendy; Artiom Petrov | Zendy; Takehiro Nakahara | Zendy; Takashi Tanimoto | Zendy; DongBin Kim | Zendy; Jiqiu Chen | Zendy; Djamel Lebeche | Zendy; Francis G. Blankenberg | Zendy; Koon Y. Pak | Zendy; Frank D. Kolodgie | Zendy; Renu Virmani | Zendy; Partho P. Sengupta | Zendy; Navneet Narula | Zendy; Roger J. Hajjar | Zendy; H. William Strausś | Zendy; Jagat Narula | Zendy

Open Access

Molecular Imaging of Apoptosis in Ischemia Reperfusion Injury With Radiolabeled Duramycin Targeting Phosphatidylethanolamine

Author(s) -

Hideki Kawai,

Farhan Chaudhry,

Aditya C. Shekhar,

Artiom Petrov,

Takehiro Nakahara,

Takashi Tanimoto,

DongBin Kim,

Jiqiu Chen,

Djamel Lebeche,

Francis G. Blankenberg,

Koon Y. Pak,

Frank D. Kolodgie,

Renu Virmani,

Partho P. Sengupta,

Navneet Narula,

Roger J. Hajjar,

H. William Strausś,

Jagat Narula

Publication year - 2018

Publication title -

jacc. cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.79

H-Index - 120

eISSN - 1936-878X

pISSN - 1876-7591

DOI - 10.1016/j.jcmg.2017.11.037

Subject(s) - phosphatidylserine , ex vivo , in vivo , annexin , ischemia , medicine , pathology , apoptosis , annexin a5 , preclinical imaging , spect imaging , nuclear medicine , chemistry , biology , phospholipid , biochemistry , staining , microbiology and biotechnology , membrane

The purpose of this study was to evaluate the feasibility of imaging apoptosis in experimental ischemia-reperfusion model by technetium-99m ( 99m Tc)-labeled Duramycin, and compare it to an established tracer, 99m Tc-labeled Annexin-V, which has a relative disadvantage of high radiation burden to nontarget organs.

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