Ultrasound-Mediated Vascular Gene Transfection by Cavitation of Endothelial-Targeted Cationic Microbubbles | Zendy

Aris Xie | Zendy; Todd Belcik | Zendy; Yue Qi | Zendy; Terry K. Morgan | Zendy; Shivam A. Champaneri | Zendy; Sarah Taylor | Zendy; Brian P. Davidson | Zendy; Yan Zhao | Zendy; Alexander L. Klibanov | Zendy; Michael A. Kuliszewski | Zendy; Howard LeongPoi | Zendy; Azzdine Y. Ammi | Zendy; Jonathan R. Lindner | Zendy

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Ultrasound-Mediated Vascular Gene Transfection by Cavitation of Endothelial-Targeted Cationic Microbubbles

Author(s) -

Aris Xie,

Todd Belcik,

Yue Qi,

Terry K. Morgan,

Shivam A. Champaneri,

Sarah Taylor,

Brian P. Davidson,

Yan Zhao,

Alexander L. Klibanov,

Michael A. Kuliszewski,

Howard LeongPoi,

Azzdine Y. Ammi,

Jonathan R. Lindner

Publication year - 2012

Publication title -

jacc. cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.79

H-Index - 120

eISSN - 1936-878X

pISSN - 1876-7591

DOI - 10.1016/j.jcmg.2012.05.017

Subject(s) - microbubbles , sonoporation , transfection , intravital microscopy , in vivo , gene delivery , biophysics , ultrasound , microbiology and biotechnology , chemistry , biomedical engineering , medicine , biology , gene , biochemistry , radiology

Ultrasound-mediated gene delivery can be amplified by acoustic disruption of microbubble carriers that undergo cavitation. We hypothesized that endothelial targeting of microbubbles bearing cDNA is feasible and, through optimizing proximity to the vessel wall, increases the efficacy of gene transfection.

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