Feasibility of [18F]-2-Fluoro-A85380-PET Imaging of Human Vascular Nicotinic Acetylcholine Receptors In Vivo | Zendy

Jan Bucerius | Zendy; Christoph Manka | Zendy; Jörn Schmaljohann | Zendy; Venkatesh Mani | Zendy; Daniela Gündisch | Zendy; James H.F. Rudd | Zendy; Rolf Bippus | Zendy; Felix M. Mottaghy | Zendy; Ullrich Wüllner | Zendy; Zahi A. Fayad | Zendy; HansJürgen Biersack | Zendy

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Feasibility of [18F]-2-Fluoro-A85380-PET Imaging of Human Vascular Nicotinic Acetylcholine Receptors In Vivo

Author(s) -

Jan Bucerius,

Christoph Manka,

Jörn Schmaljohann,

Venkatesh Mani,

Daniela Gündisch,

James H.F. Rudd,

Rolf Bippus,

Felix M. Mottaghy,

Ullrich Wüllner,

Zahi A. Fayad,

HansJürgen Biersack

Publication year - 2012

Publication title -

jacc. cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.79

H-Index - 120

eISSN - 1936-878X

pISSN - 1876-7591

DOI - 10.1016/j.jcmg.2011.11.024

Subject(s) - nicotinic agonist , nicotine , in vivo , standardized uptake value , medicine , positron emission tomography , acetylcholine receptor , descending aorta , nuclear medicine , aorta , ex vivo , receptor , pathology , biology , microbiology and biotechnology

The aim of this feasibility study was to evaluate [(18)F]-2-Fluoro-A85380 for in vivo imaging of arterial nicotinic acetylcholine receptors (nAChRs) in humans. Furthermore, potentially different vascular uptake patterns of this new tracer were evaluated in healthy volunteers and in patients with neurodegenerative disorders.

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