Diastolic Abnormalities as the First Feature of Hypertrophic Cardiomyopathy in Dutch Myosin-Binding Protein C Founder Mutations | Zendy

Michelle Michels | Zendy; Osama Soliman | Zendy; Marcel J.M. Kofflard | Zendy; Yvonne M. Hoedemaekers | Zendy; Dennis Dooijes | Zendy; Daniëlle MajoorKrakauer | Zendy; Folkert J. ten Cate | Zendy

Open Access

Diastolic Abnormalities as the First Feature of Hypertrophic Cardiomyopathy in Dutch Myosin-Binding Protein C Founder Mutations

Author(s) -

Michelle Michels,

Osama Soliman,

Marcel J.M. Kofflard,

Yvonne M. Hoedemaekers,

Dennis Dooijes,

Daniëlle MajoorKrakauer,

Folkert J. ten Cate

Publication year - 2009

Publication title -

jacc. cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.79

H-Index - 120

eISSN - 1936-878X

pISSN - 1876-7591

DOI - 10.1016/j.jcmg.2008.08.003

Subject(s) - founder effect , hypertrophic cardiomyopathy , genetics , medicine , cardiology , biology , gene , haplotype , genotype

To test the hypothesis that carriers of Dutch founder mutations in cardiac myosin-binding protein C (MYBPC3), without left ventricular hypertrophy (LVH) or electrocardiographic abnormalities, have diastolic dysfunction on tissue Doppler imaging (TDI), which can be used for the screening of family members in the hypertrophic cardiomyopathy (HCM) population.

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